Synthesis of Spirotetramates via a Diels−Alder Approach Nicholas A. Butt Christopher J. Moody 10.1021/ol200477s.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Spirotetramates_via_a_Diels_Alder_Approach/2655856 A study toward the unusual spirotetramate core of the pyrroindomycin antibiotics employing an intermolecular Diels−Alder reaction of an <i>exo</i>-methylene tetramic acid dienophile is described. The <i>exo</i>-methylene tetramate is readily synthesized from <i>S</i>-methylcysteine, and its reactivity as a dienophile is compared with that of related dehydroalanine derivatives. An alternative approach to spirotetramates using a nitroalkene dienophile is also reported. 2011-05-06 00:00:00 pyrroindomycin antibiotics Diel nitroalkene dienophile dehydroalanine derivatives alternative approach spirotetramate core