TY - DATA T1 - Cardiomyocyte hypertrophy and age-related interstitial fibrosis in ErbB2 transgenic mice. PY - 2012/08/09 AU - Polina Sysa-Shah AU - Yi Xu AU - Xin Guo AU - Frances Belmonte AU - Byunghak Kang AU - Djahida Bedja AU - Scott Pin AU - Noriko Tsuchiya AU - Kathleen Gabrielson UR - https://plos.figshare.com/articles/figure/_Cardiomyocyte_hypertrophy_and_age_related_interstitial_fibrosis_in_ErbB2_transgenic_mice_/264714 DO - 10.1371/journal.pone.0042805.g004 L4 - https://ndownloader.figshare.com/files/594229 KW - hypertrophy KW - age-related KW - interstitial KW - fibrosis KW - erbb2 KW - transgenic N2 - (A) H&E staining shows hypertrophied cardiomyocytes with enlarged nuclei in ErbB2 transgenic mice compared to wild type mice. Bar = 50 um. Masson trichrome staining was used to evaluate fibrosis in the hearts of 2 months (B) and 6 months old (C) wild type and ErbB2 transgenic mice. Bar = 50 um. (D) Representative images of WGA (wheat germ agglutinin) staining of left ventricle sections of wild type and ErbB2 transgenic mice hearts. (E) Isolated unstained cardiomyocytes from wild type and ErbB2 transgenic mice hearts. (F) Measurement of area of cardiomyocytes, isolated from wild type and ErbB2 transgenic hearts. 12–25 cardiomyocytes (3–4 mice per genotype) were used for calculations. The data are presented as the mean ± SD. All the studies were performed on 8–10 weeks old mice, unless different age is specified. ER -