10.1371/journal.pone.0042805.g004
Polina Sysa-Shah
Polina
Sysa-Shah
Yi Xu
Yi
Xu
Xin Guo
Xin
Guo
Frances Belmonte
Frances
Belmonte
Byunghak Kang
Byunghak
Kang
Djahida Bedja
Djahida
Bedja
Scott Pin
Scott
Pin
Noriko Tsuchiya
Noriko
Tsuchiya
Kathleen Gabrielson
Kathleen
Gabrielson
Cardiomyocyte hypertrophy and age-related interstitial fibrosis in ErbB2 transgenic mice.
Public Library of Science
2012
hypertrophy
age-related
interstitial
fibrosis
erbb2
transgenic
2012-08-09 01:18:34
Figure
https://plos.figshare.com/articles/figure/_Cardiomyocyte_hypertrophy_and_age_related_interstitial_fibrosis_in_ErbB2_transgenic_mice_/264714
<p>(A) H&E staining shows hypertrophied cardiomyocytes with enlarged nuclei in ErbB2 transgenic mice compared to wild type mice. Bar = 50 um. Masson trichrome staining was used to evaluate fibrosis in the hearts of 2 months (B) and 6 months old (C) wild type and ErbB2 transgenic mice. Bar = 50 um. (D) Representative images of WGA (wheat germ agglutinin) staining of left ventricle sections of wild type and ErbB2 transgenic mice hearts. (E) Isolated unstained cardiomyocytes from wild type and ErbB2 transgenic mice hearts. (F) Measurement of area of cardiomyocytes, isolated from wild type and ErbB2 transgenic hearts. 12–25 cardiomyocytes (3–4 mice per genotype) were used for calculations. The data are presented as the mean ± SD. All the studies were performed on 8–10 weeks old mice, unless different age is specified.</p>