ß-catenin increases HERG current.
Carlos Munoz
Ambrish Saxena
Tatsiana Pakladok
Evgenii Bogatikov
Jan Wilmes
Guiscard Seebohm
Michael Föller
Florian Lang
10.1371/journal.pone.0043353.g001
https://plos.figshare.com/articles/figure/_223_catenin_increases_HERG_current_/262647
<p><b>A.</b> Original tracings recorded in oocytes injected with H<sub>2</sub>0 (1), with cRNA encoding HERG (2) or HERG coexpressing ß-catenin (3). The oocytes were depolarized from −80 mV holding potential to different voltages followed by a 500 ms pulse to −60 mV evoking outward tail currents. The small insert displays the applied voltage protocol. <b>B.</b> Arithmetic means±SEM (n = 8–11) of the normalized outward tail current following a depolarization to +80 mV recorded in oocytes injected with H<sub>2</sub>0 (left bar), with cRNA encoding HERG (middle bar) or with RNA encoding HERG and ß-catenin (right bar). * indicates statistical significance (p<0.05) from the absence of ß-catenin cRNA. <b>C.</b> IV curves of outward tail currents illustrated in B (upper panel) and IV curves of outward tail currents following normalization to the maximal tail current of the respective group (lower panel).</p>
2013-02-20 00:52:34
increases
herg