Contributions of cortical and amygdalar interneurons to flexible decision-making and attention: Spiking model.
Yohan J. John
Basilis Zikopoulos
Daniel Bullock
Helen Barbas
10.1371/journal.pcbi.1004722.g010
https://plos.figshare.com/articles/figure/Contributions_of_cortical_and_amygdalar_interneurons_to_flexible_decision_making_and_attention_Spiking_model_/2614411
<p>Time evolution of a key spiking model activity, during the first two seconds of the first testing phase. Simulations and key activities of the rate-coded and spiking models were similar, with each simulation divided into 4 epochs: two conditioning phases, followed by two testing phases. <b><i>A</i>,</b> Cortical activity corresponding to the feed plan. <b><i>B</i>,</b> Cortical activity corresponding to the fear plan. Plan cortical inhibitory interneurons (black spikes) trigger resetting of the corresponding plan (blue and red spikes), allowing a new plan to be selected. <b><i>C</i>, <i>D</i>,</b> Activity in the salience map corresponding to appetitive (positive) stimuli (CS1, CS2). <b><i>E</i>,</b> Activity in the salience map corresponding to an aversive (negative) stimulus (CS3). Amygdalar inhibitory interneurons (black spikes) trigger resetting of the corresponding BA principal neuron (green spikes), allowing a new CS to be selected if it is relevant to the ongoing plan (C-E). <b><i>F</i>,</b> Activity in sensory cortex corresponding to CS1 (cyan), CS2 (orange), and CS3 (magenta). <b><i>G</i>,</b> Conditioned Stimuli reaching sensory thalamus (CSs). In A-E, the inhibitory interneuron spiking activity is shown in black.</p>
2016-02-01 23:55:27
Computational Model
selection mechanism
attentional system
affective associations
primate brain
relevance detection system
projection
Emotional Gatekeeper model
attentional symptoms
pathway
circuit
TRN
Inhibitory Thalamic Reticular Nucleus
Emotional Gatekeeper
amygdala
Attentional Selection
thalamic reticular nucleus
cortex