10.1371/journal.pcbi.1004722.g007
Yohan J. John
Yohan
J. John
Basilis Zikopoulos
Basilis
Zikopoulos
Daniel Bullock
Daniel
Bullock
Helen Barbas
Helen
Barbas
Impaired decision-making flexibility in the absense of inhibitory interneurons in plan cortex.
Public Library of Science
2016
Computational Model
selection mechanism
attentional system
affective associations
primate brain
relevance detection system
projection
Emotional Gatekeeper model
attentional symptoms
pathway
circuit
TRN
Inhibitory Thalamic Reticular Nucleus
Emotional Gatekeeper
amygdala
Attentional Selection
thalamic reticular nucleus
cortex
2016-02-01 23:55:27
Figure
https://plos.figshare.com/articles/figure/Impaired_decision_making_flexibility_in_the_absense_of_inhibitory_interneurons_in_plan_cortex_/2614393
<p>Axis and subplot labels are as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004722#pcbi.1004722.g005" target="_blank">Fig 5</a>. <b><i>A</i>,</b> Plan map. The plan cortical inhibitory interneurons are 'lesioned' in the simulation. <b><i>B</i>,</b> Salience map for appetitive (positive) stimuli. <b><i>C</i>,</b> Salience map for aversive (negative) stimuli. <b><i>D</i>, <i>E</i>, <i>F</i>,</b> Sensory map, including sensory cortex (D), sensory TRN sector (E) and sensory thalamus (F). <b><i>G</i>,</b> Input to sensory thalamus (stimuli and distractors). <b><i>H</i>,</b> Reinforcement signals and Conditioned Stimuli (CSs). During the second testing phase (to the right of the vertical dotted line) top-down bias is applied to the feed plan. The plans (A) cannot shift as in the previous simulations. Thus in the absense of inhibition onto the plan cortical neurons (triggered by expectation confirmation and violation), the decision-making flexibility of the system is degraded. (In this simulation <i>M</i><sub><i>1</i></sub> = 160 during the second testing phase).</p>