%0 Generic
%A Velvadapu, Venkata
%A Paul, Tapas
%A Wagh, Bharat
%A Glassford, Ian
%A DeBrosse, Charles
%A Andrade, Rodrigo B.
%D 2011
%T Total Synthesis of (−)-4,8,10-Tridesmethyl Telithromycin
%U https://acs.figshare.com/articles/dataset/Total_Synthesis_of_4_8_10_Tridesmethyl_Telithromycin/2613286
%R 10.1021/jo201319b.s002
%2 https://ndownloader.figshare.com/files/4263235
%K desmethyl macrolides
%K macrolide antibiotic
%K synthesis
%K novel strategy
%K 2004. Herein
%K bioactive antibiotics
%K methyl groups
%K antibiotic resistance
%K Total Synthesis
%X Novel sources of antibiotics are required to address the serious problem of antibiotic resistance. Telithromycin (2) is a third-generation macrolide antibiotic prepared from erythromycin (1) and used clinically since 2004. Herein we report the details of our efforts that ultimately led to the total synthesis of (−)-4,8,10-tridesmethyl telithromycin (3) wherein methyl groups have been replaced with hydrogens. The synthesis of desmethyl macrolides has emerged as a novel strategy for preparing bioactive antibiotics.
%I ACS Publications