%0 Generic %A Velvadapu, Venkata %A Paul, Tapas %A Wagh, Bharat %A Glassford, Ian %A DeBrosse, Charles %A Andrade, Rodrigo B. %D 2011 %T Total Synthesis of (−)-4,8,10-Tridesmethyl Telithromycin %U https://acs.figshare.com/articles/dataset/Total_Synthesis_of_4_8_10_Tridesmethyl_Telithromycin/2613286 %R 10.1021/jo201319b.s002 %2 https://ndownloader.figshare.com/files/4263235 %K desmethyl macrolides %K macrolide antibiotic %K synthesis %K novel strategy %K 2004. Herein %K bioactive antibiotics %K methyl groups %K antibiotic resistance %K Total Synthesis %X Novel sources of antibiotics are required to address the serious problem of antibiotic resistance. Telithromycin (2) is a third-generation macrolide antibiotic prepared from erythromycin (1) and used clinically since 2004. Herein we report the details of our efforts that ultimately led to the total synthesis of (−)-4,8,10-tridesmethyl telithromycin (3) wherein methyl groups have been replaced with hydrogens. The synthesis of desmethyl macrolides has emerged as a novel strategy for preparing bioactive antibiotics. %I ACS Publications