TY - DATA T1 - New Electrophilic Addition of α-Diazoesters with Ketones for Enantioselective C–N Bond Formation PY - 2011/10/05 AU - Wei Li AU - Xiaohua Liu AU - Xiaoyu Hao AU - Xiaolei Hu AU - Yangyang Chu AU - Weidi Cao AU - Song Qin AU - Changwei Hu AU - Lili Lin AU - Xiaoming Feng UR - https://acs.figshare.com/articles/journal_contribution/New_Electrophilic_Addition_of_Diazoesters_with_Ketones_for_Enantioselective_C_N_Bond_Formation/2607490 DO - 10.1021/ja2056159.s002 L4 - https://ndownloader.figshare.com/files/4257010 KW - Enantioselective KW - diazo chemistry KW - Diazoester KW - application KW - access KW - ee KW - Formation KW - functionalization KW - method KW - enantioselectivitie KW - electrophile KW - diversity KW - diazoester KW - New Electrophilic Addition KW - Ketone KW - formation KW - novel way KW - Bond KW - yield KW - ketone KW - electrophilicity KW - bond N2 - α-Diazoesters were discovered to be good electrophiles in a catalytic asymmetric α-functionalization of ketones for the first time. This reaction also provided a direct and efficient method for C–N bond formation with excellent yields (up to 98%) and enantioselectivities (up to 99% ee) under mild conditions. The application of the electrophilicity of α-diazoesters opens up a novel way to access the diversity of diazo chemistry. ER -