TY - DATA T1 - Coumarin-Cu(II) Ensemble-Based Cyanide Sensing Chemodosimeter PY - 2011/10/07 AU - Hyo Sung Jung AU - Ji Hye Han AU - Zee Hwan Kim AU - Chulhun Kang AU - Jong Seung Kim UR - https://acs.figshare.com/articles/journal_contribution/Coumarin_Cu_II_Ensemble_Based_Cyanide_Sensing_Chemodosimeter/2605465 DO - 10.1021/ol2018856.s001 L4 - https://ndownloader.figshare.com/files/4254817 KW - HepG 2 cells KW - hydrolytic cleavage KW - cyanide ion KW - nonfluorescent 1 KW - Schiff base KW - cyanide detection KW - fluorescence enhancement KW - Cu N2 - An “ensemble”-based chemodosimeter 1–Cu(II) for cyanide detection is reported. 1–Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. “Off–on” fluorescence change of 1–Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1–Cu(II) for biological application was also performed in HepG2 cells. ER -