TY - DATA T1 - Dexamethasone release rates from guinea pig electrode measured in vitro. PY - 2016/02/03 AU - Maciej Wilk AU - Roland Hessler AU - Kenneth Mugridge AU - Claude Jolly AU - Michael Fehr AU - Thomas Lenarz AU - Verena Scheper UR - https://plos.figshare.com/articles/figure/Dexamethasone_release_rates_from_guinea_pig_electrode_measured_in_vitro_/2603887 DO - 10.1371/journal.pone.0147552.g003 L4 - https://ndownloader.figshare.com/files/4253002 KW - round window membrane approach KW - implantation impedance levels KW - round window niche KW - DEX KW - Dexamethasone Eluting Electrode BackgroundThe efficiency KW - attenuating electrode impedance KW - CI electrode arrays KW - electrode array KW - tissue growth KW - guinea pig cochleae KW - auditory brainstem responses KW - Fibrous Tissue Growth N2 - The first 4 mm of the electrode array were immersed into 1 ml of saline solution at 37°C. The saline solution was periodically sampled and DEX concentrations were measured by HPLC-MS (Agilent 1200 HPLC coupled with a Bruker MicrOTOF-Q II MS-detector). Representative release profile measurements for the 1% (red squares) and 10% (blue triangles) DEX loaded electrodes are shown. Over the experimental time period (91 days) the average release rate of DEX from the 1% and 10% loaded electrodes was estimated to be in the order of 16 ng/day and 49 ng/day respectively. DEX release rates were higher in the initial elution period (e.g. average over the first five days: 62 ng/day and 166 ng/day respectively for the 1% and 10% electrodes) with a slow decay over time. ER -