Shiozaki, Atsushi Shen-Tu, Grace Bai, Xiaohui Iitaka, Daisuke De Falco, Valentina Santoro, Massimo Keshavjee, Shaf Liu, Mingyao XB130 controls cell cycle progression of cancer cells. <p>(A and B) Down-regulation of XB130 inhibited G<sub>1</sub>-S phase progression in WRO and A549 cells. Cells transfected with control or XB130 siRNA were stained with PI and analyzed by flow cytometry. Mean ± SEM. <i>n</i> = 6. *<i>p</i><0.05 (compared with control siRNA). (C) Reduced Ki67 and PCNA levels in XB130 siRNA treated WRO and A549 cells, as determined by western blotting. <i>n</i> = 3. *<i>p</i><0.05 (compared with control siRNA treated group). (D) Presence of RET/PTC rearrangement was confirmed in both TPC-1 and WRO cells using RT-PCR. A549 cells do not contain RET/PTC rearrangement.</p> controls;progression;cancer 2012-08-23
    https://plos.figshare.com/articles/figure/_XB130_controls_cell_cycle_progression_of_cancer_cells_/258049
10.1371/journal.pone.0043646.g001