10.1371/journal.pone.0043646.g001 Atsushi Shiozaki Atsushi Shiozaki Grace Shen-Tu Grace Shen-Tu Xiaohui Bai Xiaohui Bai Daisuke Iitaka Daisuke Iitaka Valentina De Falco Valentina De Falco Massimo Santoro Massimo Santoro Shaf Keshavjee Shaf Keshavjee Mingyao Liu Mingyao Liu XB130 controls cell cycle progression of cancer cells. Public Library of Science 2012 controls progression cancer 2012-08-23 02:14:09 Figure https://plos.figshare.com/articles/figure/_XB130_controls_cell_cycle_progression_of_cancer_cells_/258049 <p>(A and B) Down-regulation of XB130 inhibited G<sub>1</sub>-S phase progression in WRO and A549 cells. Cells transfected with control or XB130 siRNA were stained with PI and analyzed by flow cytometry. Mean ± SEM. <i>n</i> = 6. *<i>p</i><0.05 (compared with control siRNA). (C) Reduced Ki67 and PCNA levels in XB130 siRNA treated WRO and A549 cells, as determined by western blotting. <i>n</i> = 3. *<i>p</i><0.05 (compared with control siRNA treated group). (D) Presence of RET/PTC rearrangement was confirmed in both TPC-1 and WRO cells using RT-PCR. A549 cells do not contain RET/PTC rearrangement.</p>