Wu, Chun-Fang Zhao, Xin Lan, Wen-Xian Cao, Chunyang Liu, Jin-Tao Jiang, Xi-Kui Li, Zhan-Ting A 1,4-Diphenyl-1,2,3-Triazole-Based β-Turn Mimic Constructed by Click Chemistry A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) <sup>1</sup>H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C–H···O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as β-turn mimic. To prove this, the formation of a β-hairpin structure induced by this β-turn motif has been further demonstrated. ether O atoms;motif;skeleton;compound;hairpin;Diphenyl;intramolecular;candidate;diphenyl;derivative;Mimic Constructed;conformation;H atom;formation;1 H NMR studies;2 D;amide;triazole C;Click ChemistryA series;Such 2012-05-04
    https://acs.figshare.com/articles/dataset/A_1_4_Diphenyl_1_2_3_Triazole_Based_Turn_Mimic_Constructed_by_Click_Chemistry/2525230
10.1021/jo300063u.s001