A 1,4-Diphenyl-1,2,3-Triazole-Based β-Turn Mimic Constructed by Click Chemistry WuChun-Fang ZhaoXin LanWen-Xian CaoChunyang LiuJin-Tao JiangXi-Kui LiZhan-Ting 2012 A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) <sup>1</sup>H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C–H···O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as β-turn mimic. To prove this, the formation of a β-hairpin structure induced by this β-turn motif has been further demonstrated.