Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base-Free Conditions Chao Dai Zhaoqing Xu Fei Huang Zhengkun Yu Yan-Feng Gao 10.1021/jo202624s.s001 https://acs.figshare.com/articles/journal_contribution/Lewis_Acid_Catalyzed_Copper_II_Mediated_Synthesis_of_Heteroaryl_Thioethers_under_Base_Free_Conditions/2525200 A Lewis acid (Ag<sup>I</sup>, Ni<sup>II</sup>, or Fe<sup>II</sup>) catalyzed, Cu<sup>II</sup>-mediated thiolation reaction between heteroarenes and thiols was achieved with good yield under base-free conditions. DMSO could serve as an effective methylthiolation reagent for the synthesis of heterocyclic methyl thioethers. 2016-02-21 12:32:47 Heteroaryl Thioethers ConditionsA heteroarene acid heterocyclic methyl thioethers synthesis Synthesi FeII NiII methylthiolation reagent AgI Lewis DMSO