TY - DATA T1 - Lipase Is Essential for the Study of in Vitro Release Kinetics from Organogels PY - 2016/02/20 AU - Marie-Hélène Dufresne AU - Elaheh Marouf AU - Yvonne Kränzlin AU - Marc A. Gauthier AU - Jean-Christophe Leroux UR - https://acs.figshare.com/articles/journal_contribution/Lipase_Is_Essential_for_the_Study_of_i_in_Vitro_i_Release_Kinetics_from_Organogels/2517499 DO - 10.1021/mp3001099.s001 L4 - https://ndownloader.figshare.com/files/4160428 KW - drug release studies KW - drug release kinetics KW - drug loadings KW - implant KW - Lipase KW - drug release KW - vivo data KW - drug delivery systems KW - organogelator concentrations KW - Vitro Release Kinetics KW - analysis method KW - vivo results N2 - In vitro drug release studies remain indispensable in the development of drug delivery systems, even if correlations between in vitro and in vivo results are often imperfect. In this work, an improved in vitro analysis method for studying in situ-forming lipid-based implants was developed. More specifically, lipase was found to be an essential additive for evidencing differences in drug release kinetics from organogels of different amino acid-based organogelators, organogelator concentrations, drug loadings, and volumes. Lipases are thought to participate in the degradation of and release from amino acid-based organogel implants in vivo. Our experimental conditions allowed for the rapid and reliable screening of in vitro parameters that may be optimized to slow or accelerate drug release, once preliminary in vivo data are available. ER -