10.1021/mp3001099.s001
Marie-Hélène Dufresne
Marie-Hélène
Dufresne
Elaheh Marouf
Elaheh
Marouf
Yvonne Kränzlin
Yvonne
Kränzlin
Marc A. Gauthier
Marc A.
Gauthier
Jean-Christophe Leroux
Jean-Christophe
Leroux
Lipase Is Essential for
the Study of <i>in Vitro</i> Release Kinetics from Organogels
American Chemical Society
2016
drug release studies
drug release kinetics
drug loadings
implant
Lipase
drug release
vivo data
drug delivery systems
organogelator concentrations
Vitro Release Kinetics
analysis method
vivo results
2016-02-20 20:30:22
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Lipase_Is_Essential_for_the_Study_of_i_in_Vitro_i_Release_Kinetics_from_Organogels/2517499
<i>In vitro</i> drug release studies remain
indispensable
in the development of drug delivery systems, even if correlations
between <i>in vitro</i> and <i>in vivo</i> results
are often imperfect. In this work, an improved <i>in vitro</i> analysis method for studying <i>in situ</i>-forming lipid-based
implants was developed. More specifically, lipase was found to be
an essential additive for evidencing differences in drug release kinetics
from organogels of different amino acid-based organogelators,
organogelator concentrations, drug loadings, and volumes. Lipases
are thought to participate in the degradation of and release from
amino acid-based organogel implants <i>in vivo</i>. Our
experimental conditions allowed for the rapid and reliable screening
of <i>in vitro</i> parameters that may be optimized to slow
or accelerate drug release, once preliminary <i>in vivo</i> data are available.