10.1021/mp3001099.s001 Marie-Hélène Dufresne Marie-Hélène Dufresne Elaheh Marouf Elaheh Marouf Yvonne Kränzlin Yvonne Kränzlin Marc A. Gauthier Marc A. Gauthier Jean-Christophe Leroux Jean-Christophe Leroux Lipase Is Essential for the Study of <i>in Vitro</i> Release Kinetics from Organogels American Chemical Society 2016 drug release studies drug release kinetics drug loadings implant Lipase drug release vivo data drug delivery systems organogelator concentrations Vitro Release Kinetics analysis method vivo results 2016-02-20 20:30:22 Journal contribution https://acs.figshare.com/articles/journal_contribution/Lipase_Is_Essential_for_the_Study_of_i_in_Vitro_i_Release_Kinetics_from_Organogels/2517499 <i>In vitro</i> drug release studies remain indispensable in the development of drug delivery systems, even if correlations between <i>in vitro</i> and <i>in vivo</i> results are often imperfect. In this work, an improved <i>in vitro</i> analysis method for studying <i>in situ</i>-forming lipid-based implants was developed. More specifically, lipase was found to be an essential additive for evidencing differences in drug release kinetics from organogels of different amino acid-based organogelators, organogelator concentrations, drug loadings, and volumes. Lipases are thought to participate in the degradation of and release from amino acid-based organogel implants <i>in vivo</i>. Our experimental conditions allowed for the rapid and reliable screening of <i>in vitro</i> parameters that may be optimized to slow or accelerate drug release, once preliminary <i>in vivo</i> data are available.