10.1021/ic3005085.s001 Manolis J. Manos Manolis J. Manos Eleni J. Kyprianidou Eleni J. Kyprianidou Giannis S. Papaefstathiou Giannis S. Papaefstathiou Anastasios J. Tasiopoulos Anastasios J. Tasiopoulos Insertion of Functional Groups into a Nd<sup>3+</sup> Metal–Organic Framework via Single-Crystal-to-Single-Crystal Coordinating Solvent Exchange American Chemical Society 2012 postsynthetic introduction SH NH guest molecules terminally ligating solvents science point UCY Functional Groups chelating ligands Nd SCSC transformations OH MOF 2012-06-04 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Insertion_of_Functional_Groups_into_a_Nd_sup_3_sup_Metal_Organic_Framework_via_Single_Crystal_to_Single_Crystal_Coordinating_Solvent_Exchange/2517364 Single-crystal-to-single-crystal (SCSC) transformations represent some of the most fascinating phenomena in chemistry. They are not only intriguing from a basic science point of view but also provide a means to modify or tune the properties of the materials via the postsynthetic introduction of suitable guest molecules or organic functional groups into their structures. Here, we describe <b>UCY-2</b>, a new flexible Nd<sup>3+</sup> metal–organic framework (MOF), which exhibits a unique capability to undergo a plethora of SCSC transformations with some of them being very uncommon. These structural alterations involve the replacement of coordinating solvent molecules of <b>UCY-2</b> by terminally ligating solvents and organic ligands with multiple functional groups including −OH, −SH, −NH–, and −NH<sub>2</sub> or their combinations, chelating ligands, anions, and two different organic compounds. The SCSC coordinating solvent exchange is thus demonstrated as a powerful method for the functionalization of MOFs.