10.1021/jp304708y.s001
Miguel Gomez-Mendoza
Miguel
Gomez-Mendoza
Edurne Nuin
Edurne
Nuin
Inmaculada Andreu
Inmaculada
Andreu
M. Luisa Marin
M. Luisa
Marin
Miguel A. Miranda
Miguel A.
Miranda
Photophysical Probes To
Assess the Potential
of Cholic Acid Aggregates as Drug Carriers
American Chemical Society
2012
photoactive chromophore
photophysical methodology
photophysical techniques
representative probes
methyl ester
nitrite anions
nonsteroidal antiinflammatory drug naproxen
drug carriers
cholic acid aggregates
Photophysical Probes
bulk solution
Drug CarriersThe
2012-08-30 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Photophysical_Probes_To_Assess_the_Potential_of_Cholic_Acid_Aggregates_as_Drug_Carriers/2491918
The two enantiomers of the nonsteroidal antiinflammatory
drug naproxen
and of its methyl ester have been selected as representative probes
with markedly different hydrophobicity to assess the potential of
cholic acid aggregates as drug carriers by means of photophysical
techniques. The different distribution of the probes between bulk
solution and aggregates has been assessed by quenching of their singlet
and triplet excited states by iodide and nitrite anions, respectively.
This straightforward photophysical methodology can, in principle,
be extended to a variety of drugs containing a photoactive chromophore.