10.1021/jp304708y.s001 Miguel Gomez-Mendoza Miguel Gomez-Mendoza Edurne Nuin Edurne Nuin Inmaculada Andreu Inmaculada Andreu M. Luisa Marin M. Luisa Marin Miguel A. Miranda Miguel A. Miranda Photophysical Probes To Assess the Potential of Cholic Acid Aggregates as Drug Carriers American Chemical Society 2012 photoactive chromophore photophysical methodology photophysical techniques representative probes methyl ester nitrite anions nonsteroidal antiinflammatory drug naproxen drug carriers cholic acid aggregates Photophysical Probes bulk solution Drug CarriersThe 2012-08-30 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Photophysical_Probes_To_Assess_the_Potential_of_Cholic_Acid_Aggregates_as_Drug_Carriers/2491918 The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid aggregates as drug carriers by means of photophysical techniques. The different distribution of the probes between bulk solution and aggregates has been assessed by quenching of their singlet and triplet excited states by iodide and nitrite anions, respectively. This straightforward photophysical methodology can, in principle, be extended to a variety of drugs containing a photoactive chromophore.