%0 Journal Article
%A Gore, Sangram
%A Baskaran, Sundarababu
%A König, Burkhard
%D 2012
%T Fischer Indole Synthesis in Low Melting Mixtures
%U https://acs.figshare.com/articles/journal_contribution/Fischer_Indole_Synthesis_in_Low_Melting_Mixtures/2489707
%R 10.1021/ol302034r.s001
%2 https://ndownloader.figshare.com/files/4132495
%K reaction conditions
%K hormone melatonin
%K acid
%K synthezised
%K tartaric
%K Fischer Indole Synthesis
%K indolenine
%K Low Melting MixturesFunctionalized indoles
%K catalyst
%K azide
%K yield
%K method
%K synthesis
%K regioselectively
%X Functionalized indoles are synthezised under mild conditions in a tartaric acid–dimethylurea melt. The melt serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are stable, and indolenines are obtained regioselectively in excellent yields. The practical use of the method is demonstrated in the synthesis of the hormone melatonin.
%I ACS Publications