%0 Journal Article %A Gore, Sangram %A Baskaran, Sundarababu %A König, Burkhard %D 2012 %T Fischer Indole Synthesis in Low Melting Mixtures %U https://acs.figshare.com/articles/journal_contribution/Fischer_Indole_Synthesis_in_Low_Melting_Mixtures/2489707 %R 10.1021/ol302034r.s001 %2 https://ndownloader.figshare.com/files/4132495 %K reaction conditions %K hormone melatonin %K acid %K synthezised %K tartaric %K Fischer Indole Synthesis %K indolenine %K Low Melting MixturesFunctionalized indoles %K catalyst %K azide %K yield %K method %K synthesis %K regioselectively %X Functionalized indoles are synthezised under mild conditions in a tartaric acid–dimethylurea melt. The melt serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are stable, and indolenines are obtained regioselectively in excellent yields. The practical use of the method is demonstrated in the synthesis of the hormone melatonin. %I ACS Publications