Wharton-Fragmentation-Based Approach to the Carbocyclic Core of the Phomoidrides Graham K. Murphy Naoto Hama Aaron Bedermann Ping Dong Chris M. Schneider Travis C. McMahon Ran N. Tao Barry M. Twenter David A. Spiegel John L. Wood 10.1021/ol302011b.s001 https://acs.figshare.com/articles/journal_contribution/Wharton_Fragmentation_Based_Approach_to_the_Carbocyclic_Core_of_the_Phomoidrides/2489701 The carbocyclic core of the phomoidrides has been synthesized efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels–Alder sequence, tandem radical cyclization, and a late-stage Wharton fragmentation of a densely functionalized isotwistane skeleton. 2012-09-07 00:00:00 sequence phomoidride Approach Key steps cyclization Wharton Diel Carbocyclic Core phenolic oxidation tandem fragmentation PhomoidridesThe carbocyclic core functionalized isotwistane skeleton