10.1021/ol302011b.s001 Graham K. Murphy Graham K. Murphy Naoto Hama Naoto Hama Aaron Bedermann Aaron Bedermann Ping Dong Ping Dong Chris M. Schneider Chris M. Schneider Travis C. McMahon Travis C. McMahon Ran N. Tao Ran N. Tao Barry M. Twenter Barry M. Twenter David A. Spiegel David A. Spiegel John L. Wood John L. Wood Wharton-Fragmentation-Based Approach to the Carbocyclic Core of the Phomoidrides American Chemical Society 2012 sequence phomoidride Approach Key steps cyclization Wharton Diel Carbocyclic Core phenolic oxidation tandem fragmentation PhomoidridesThe carbocyclic core functionalized isotwistane skeleton 2012-09-07 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Wharton_Fragmentation_Based_Approach_to_the_Carbocyclic_Core_of_the_Phomoidrides/2489701 The carbocyclic core of the phomoidrides has been synthesized efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels–Alder sequence, tandem radical cyclization, and a late-stage Wharton fragmentation of a densely functionalized isotwistane skeleton.