Chooi, Yit-Heng Fang, Jinxu Liu, Hong Filler, Scott G. Wang, Pin Tang, Yi Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in <i>Aspergillus fumigatus</i> and <i>Neosartorya fischeri</i> led to isolation of a new metabolite neosartoricin (<b>3</b>). The structure of <b>3</b> was solved by X-ray crystallography and NMR to be a prenylated anthracenone. <b>3</b> exhibits T-cell antiproliferative activity with an IC<sub>50</sub> of 3 μM, suggestive of a physiological role as an immunosuppressive agent. exhibit;agent;antiproliferative;cluster;crystallography;genome Mining;Aspergillus fumigatus;Prenylated;pcPTase;neosartoricin;role;IC 50;prenylated anthracenone;NMR;Immunosuppressive Polyketide;Pathogenic FungiActivation;metabolite;Neosartorya fischeri;3 μ M;polycyclic polyketide prenyltransferase;isolation 2013-02-15
    https://acs.figshare.com/articles/dataset/Genome_Mining_of_a_Prenylated_and_Immunosuppressive_Polyketide_from_Pathogenic_Fungi/2442934
10.1021/ol303435y.s002