Enantioselective Synthesis of 4,5-Dihydropyrroles via Domino Ring-Opening Cyclization (DROC) of <i>N</i>‑Activated Aziridines with Malononitrile Manas K. Ghorai Deo Prakash Tiwari 10.1021/jo302815m.s001 https://acs.figshare.com/articles/journal_contribution/Enantioselective_Synthesis_of_4_5_Dihydropyrroles_via_Domino_Ring_Opening_Cyclization_DROC_of_i_N_i_Activated_Aziridines_with_Malononitrile/2433889 An efficient and practical strategy for the synthesis of highly functionalized racemic and non-racemic 4,5-dihydropyrroles via domino ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and stereoselectivity is described. The reaction serves as a tool for the synthesis of a large variety of substituted 4,5-dihydropyrroles in enantiomerically pure forms. 2013-03-15 00:00:00 cyclization domino Cyclization functionalized racemic enantiomerically variety dihydropyrrole strategy DROC MalononitrileAn synthesis Dihydropyrrole tool stereoselectivity Aziridine Domino malononitrile Enantioselective Synthesis aziridine