Enantioselective Synthesis of 4,5-Dihydropyrroles
via Domino Ring-Opening Cyclization (DROC) of <i>N</i>‑Activated
Aziridines with Malononitrile
Manas K. Ghorai
Deo Prakash Tiwari
10.1021/jo302815m.s001
https://acs.figshare.com/articles/journal_contribution/Enantioselective_Synthesis_of_4_5_Dihydropyrroles_via_Domino_Ring_Opening_Cyclization_DROC_of_i_N_i_Activated_Aziridines_with_Malononitrile/2433889
An efficient and practical strategy
for the synthesis of highly
functionalized racemic and non-racemic 4,5-dihydropyrroles via domino
ring-opening cyclization (DROC) of activated aziridines with malononitrile
in excellent yield and stereoselectivity is described. The reaction
serves as a tool for the synthesis of a large variety of substituted
4,5-dihydropyrroles in enantiomerically pure forms.
2013-03-15 00:00:00
cyclization
domino
Cyclization
functionalized racemic
enantiomerically
variety
dihydropyrrole
strategy
DROC
MalononitrileAn
synthesis
Dihydropyrrole
tool
stereoselectivity
Aziridine
Domino
malononitrile
Enantioselective Synthesis
aziridine