10.1021/np300750q.s003 Liva Harinantenaina Liva Harinantenaina Jessica D. Bowman Jessica D. Bowman Peggy J. Brodie Peggy J. Brodie Carla Slebodnick Carla Slebodnick Martin W. Callmander Martin W. Callmander Etienne Rakotobe Etienne Rakotobe Richard Randrianaivo Richard Randrianaivo Vincent E. Rasamison Vincent E. Rasamison Alexander Gorka Alexander Gorka Paul D. Roepe Paul D. Roepe Maria B. Cassera Maria B. Cassera David G. I. Kingston David G. I. Kingston Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from <i>Mallotus oppositifolius</i> from the Madagascar Dry Forest American Chemical Society 2016 6.3 falciparum 1.10 assay antimalarial compound antiproliferative Antiplasmodial Dimeric Phloroglucinols fractionation crystal Compound IC 50 values mallotophenone spectroscopic ethanol inflorescence bioactive 0.30 Plasmodium basis 0.04 cancer cell line mallotojaponin phloroglucinol isolation dimeric Antiproliferative spectrometry Madagascar 1.3 0.1 0.4 evidence Mallotus oppositifolius 0.75 0.14 spectra 2016-02-19 16:25:48 Dataset https://acs.figshare.com/articles/dataset/Antiproliferative_and_Antiplasmodial_Dimeric_Phloroglucinols_from_i_Mallotus_oppositifolius_i_from_the_Madagascar_Dry_Forest/2431951 Bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of <i>Mallotus oppositifolius</i> collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotojaponins B (<b>1</b>) and C (<b>2</b>), together with the known mallotophenone (<b>3</b>). The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, mass spectrometry, and an X-ray crystal structure. Compounds <b>1</b> and <b>2</b> showed potent antimalarial activity against chloroquine-resistant <i>Plasmodium falciparum,</i> with IC<sub>50</sub> values of 0.75 ± 0.30 and 0.14 ± 0.04 μM, while <b>3</b> was inactive in this assay. Compounds <b>1</b>–<b>3</b> also displayed strong antiproliferative activity against the A2780 human ovarian cancer cell line (IC<sub>50</sub> 1.10 ± 0.05, 1.3 ± 0.1 and 6.3 ± 0.4 μM, respectively).