10.1021/np300750q.s003
Liva Harinantenaina
Liva
Harinantenaina
Jessica D. Bowman
Jessica D.
Bowman
Peggy J. Brodie
Peggy J.
Brodie
Carla Slebodnick
Carla
Slebodnick
Martin W. Callmander
Martin W.
Callmander
Etienne Rakotobe
Etienne
Rakotobe
Richard Randrianaivo
Richard
Randrianaivo
Vincent E. Rasamison
Vincent E.
Rasamison
Alexander Gorka
Alexander
Gorka
Paul D. Roepe
Paul D.
Roepe
Maria B. Cassera
Maria B.
Cassera
David G. I. Kingston
David
G. I. Kingston
Antiproliferative and
Antiplasmodial Dimeric Phloroglucinols from <i>Mallotus oppositifolius</i> from the Madagascar Dry Forest
American Chemical Society
2016
6.3
falciparum
1.10
assay
antimalarial
compound
antiproliferative
Antiplasmodial Dimeric Phloroglucinols
fractionation
crystal
Compound
IC 50 values
mallotophenone
spectroscopic
ethanol
inflorescence
bioactive
0.30
Plasmodium
basis
0.04
cancer cell line
mallotojaponin
phloroglucinol
isolation
dimeric
Antiproliferative
spectrometry
Madagascar
1.3
0.1
0.4
evidence
Mallotus oppositifolius
0.75
0.14
spectra
2016-02-19 16:25:48
Dataset
https://acs.figshare.com/articles/dataset/Antiproliferative_and_Antiplasmodial_Dimeric_Phloroglucinols_from_i_Mallotus_oppositifolius_i_from_the_Madagascar_Dry_Forest/2431951
Bioassay-guided fractionation of an ethanol extract of
the leaves
and inflorescence of <i>Mallotus oppositifolius</i> collected
in Madagascar led to the isolation of the two new bioactive dimeric
phloroglucinols mallotojaponins B (<b>1</b>) and C (<b>2</b>), together with the known mallotophenone (<b>3</b>). The structures
of the new compounds were determined on the basis of spectroscopic
evidence, including their 1D- and 2D-NMR spectra, mass spectrometry,
and an X-ray crystal structure. Compounds <b>1</b> and <b>2</b> showed potent antimalarial activity against chloroquine-resistant <i>Plasmodium falciparum,</i> with IC<sub>50</sub> values of 0.75
± 0.30 and 0.14 ± 0.04 μM, while <b>3</b> was
inactive in this assay. Compounds <b>1</b>–<b>3</b> also displayed strong antiproliferative activity against the A2780
human ovarian cancer cell line (IC<sub>50</sub> 1.10 ± 0.05,
1.3 ± 0.1 and 6.3 ± 0.4 μM, respectively).