10.1021/ja401385v.s001
Maciej
A. Walczak
Maciej
A.
Walczak
Joji Hayashida
Joji
Hayashida
Samuel J. Danishefsky
Samuel J.
Danishefsky
Building Biologics by Chemical Synthesis: Practical
Preparation of Di- and Triantennary <i>N</i>‑Linked
Glycoconjugates
American Chemical Society
2013
glycosylation strategy
triantennary
PSMA oligopeptide
conjugation
Chemical Synthesis
Di
sialylated
Practical Preparation
synthesis
glycan
synthese
undeca
GlycoconjugatesA
Triantennary
tetradecasaccharide
building Biologics
yield
2013-03-27 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Building_Biologics_by_Chemical_Synthesis_Practical_Preparation_of_Di_and_Triantennary_i_N_i_Linked_Glycoconjugates/2430811
A unified
strategy for the syntheses of bi- and triantennary fully
sialylated <i>N</i>-glycans is described. The synthesis
capitalizes on a global glycosylation strategy that delivers the desired
undeca- and tetradecasaccharide in excellent yields. Finally, conjugation
of the glycan to PSMA oligopeptide is described.