10.1021/jo400274s.s002 Xiaojun Zeng Xiaojun Zeng Raymond Smith Raymond Smith Xiangming Zhu Xiangming Zhu Synthesis of Thioglycoside Analogues of Maradolipid American Chemical Society 2013 Subsequent thioglycosidic thiotrehalose laboratory Schmidt procedure Synthesi group manipulation unsymmetrical thiomaradolipids MaradolipidWe thioglycoside analogues stereoselectivity linkage acid Thioglycoside Analogues synthesis 2013-04-19 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Synthesis_of_Thioglycoside_Analogues_of_Maradolipid/2422429 We describe here the first synthesis of thioglycoside analogues of maradolipid, based on a new procedure for the synthesis of 1-thiotrehalose developed recently in our laboratories. The challenging α,α-(1→1′) thioglycosidic linkage was constructed by Schmidt’s inverse procedure in very high yield and excellent stereoselectivity. Subsequent protecting group manipulation and coupling with different fatty acids led smoothly to a group of symmetrical and unsymmetrical thiomaradolipids which would be of high value for biological studies.