TY - DATA T1 - (M)- and (P)‑Bicelaphanol A, Dimeric Trinorditerpenes with Promising Neuroprotective Activity from Celastrus orbiculatus PY - 2013/04/26 AU - Luo-Yi Wang AU - Jian Wu AU - Zhuo Yang AU - Xu-Jie Wang AU - Yan Fu AU - Shuang-Zhu Liu AU - Hong-Min Wang AU - Wei-Liang Zhu AU - Hai-Yan Zhang AU - Wei-Min Zhao UR - https://acs.figshare.com/articles/journal_contribution/_i_M_i_and_i_P_i_Bicelaphanol_A_Dimeric_Trinorditerpenes_with_Promising_Neuroprotective_Activity_from_i_Celastrus_orbiculatus_i_/2420491 DO - 10.1021/np3008182.s001 L4 - https://ndownloader.figshare.com/files/4062241 KW - dimeric trinorditerpenes KW - diffraction KW - Dimeric Trinorditerpenes KW - configuration KW - 1 μ M KW - compounds 2 KW - viability KW - 10 μ M KW - Compound 1 KW - root bark KW - spectroscopic KW - Celastrus orbiculatus KW - Promising Neuroprotective Activity KW - PC 12 cells KW - analyses KW - neuroprotective effect KW - monomer celaphanol KW - atropisomer N2 - (M)-Bicelaphanol A (1) and (P)-bicelaphanol A (2), two unprecedented dimeric trinorditerpenes existing as atropisomers, together with their monomer celaphanol A (3), were isolated from the root bark of Celastrus orbiculatus. The structures and absolute configurations of 1 and 2 were determined by spectroscopic and single-crystal X-ray diffraction analyses. Compound 1 exhibited a significant in vitro neuroprotective effect against a hydrogen peroxide-induced cell viability decrease in PC12 cells at 1 μM, while compounds 2 and 3 showed such effects at 10 μM. ER -