10.1021/am4006397.s001
Wesley
L. Storm
Wesley
L.
Storm
Mark H. Schoenfisch
Mark H.
Schoenfisch
Nitric Oxide-Releasing Xerogels Synthesized from <i>N</i>‑Diazeniumdiolate-Modified Silane Precursors
American Chemical Society
2013
material
mol
release
glucose biosensor characteristics
24 mM glucose
sensor membrane
alkoxysilane backbone identity
R 2
biosensor membrane applications
xerogel networks
aminosilane structure
glucose biosensors
reaction time
silane ratio
7 days
base catalyst concentration
2013-06-12 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nitric_Oxide_Releasing_Xerogels_Synthesized_from_i_N_i_Diazeniumdiolate_Modified_Silane_Precursors/2405608
Nitric oxide (NO)-releasing xerogel
materials were synthesized
using <i>N-</i>diazeniumdiolate-modified silane monomers
that were subsequently co-condensed with an alkoxysilane. The NO-release
characteristics were tuned by varying the aminosilane structure and
concentration. The resulting materials exhibited maximum NO release
totals and durations ranging from 0.45–3.2 μmol cm<sup>–2</sup> and 20–90 h, respectively. The stability of
the xerogel networks was optimized by varying the alkoxysilane backbone
identity, water to silane ratio, base catalyst concentration, reaction
time, and drying conditions. The response of glucose biosensors prepared
using the NO-releasing xerogel (15 mol % <i>N</i>-diazeniumdiolate-modified <i>N-</i>2-(aminoethyl)-aminopropyltrimethoxysilane) as an outer
sensor membrane was linear (<i>R</i><sup>2</sup> = 0.979)
up to 24 mM glucose. The sensitivity (3.4 nA mM<sup>–1</sup>) of the device to glucose was maintained for 7 days in phosphate
buffered saline. The facile sol–gel synthetic route, along
with the NO release and glucose biosensor characteristics, demonstrates
the versatility of this method for biosensor membrane applications.