A Novel Tandem Sequence to Pyrrole Syntheses by 5-<i>endo</i>-<i>dig</i> Cyclization of 1,3-Enynes with Amines
Ganesan Bharathiraja
Sekarpandi Sakthivel
Mani Sengoden
Tharmalingam Punniyamurthy
10.1021/ol402305b.s002
https://acs.figshare.com/articles/dataset/A_Novel_Tandem_Sequence_to_Pyrrole_Syntheses_by_5_i_endo_i_i_dig_i_Cyclization_of_1_3_Enynes_with_Amines/2370325
The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions.
2016-02-18 18:12:44
Enyne
pentasubstituted pyrroles
iodine
Cyclization
oxidative aromatization
AminesThe synthesis
enyne
sequential
Novel Tandem Sequence
amines
iodocyclization
tandem
ambient conditions
Pyrrole Syntheses
target products