10.1021/ol402305b.s002
Ganesan Bharathiraja
Ganesan
Bharathiraja
Sekarpandi Sakthivel
Sekarpandi
Sakthivel
Mani Sengoden
Mani
Sengoden
Tharmalingam Punniyamurthy
Tharmalingam
Punniyamurthy
A Novel Tandem Sequence to Pyrrole Syntheses by 5-<i>endo</i>-<i>dig</i> Cyclization of 1,3-Enynes with Amines
American Chemical Society
2016
Enyne
pentasubstituted pyrroles
iodine
Cyclization
oxidative aromatization
AminesThe synthesis
enyne
sequential
Novel Tandem Sequence
amines
iodocyclization
tandem
ambient conditions
Pyrrole Syntheses
target products
2016-02-18 18:12:44
Dataset
https://acs.figshare.com/articles/dataset/A_Novel_Tandem_Sequence_to_Pyrrole_Syntheses_by_5_i_endo_i_i_dig_i_Cyclization_of_1_3_Enynes_with_Amines/2370325
The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions.