10.1371/journal.pone.0148980.g007 Liv-Marie Eike Liv-Marie Eike Brynjar Mauseth Brynjar Mauseth Ketil André Camilio Ketil André Camilio Øystein Rekdal Øystein Rekdal Baldur Sveinbjørnsson Baldur Sveinbjørnsson Intratumoral treatment induced complete regression in B16F1 melanomas. Public Library of Science 2016 immunotherapeutic agent cancer cell lines pattern molecules DAMP Melanoma Cells lytic cell death cytoplasmic vacuolization intratumoural injections LTX cell death action studies B 16 Melanoma murine melanoma model 2016-02-16 07:56:29 Figure https://plos.figshare.com/articles/figure/Intratumoral_treatment_induced_complete_regression_in_B16F1_melanomas_/2343448 <p>(A) The intratumoral treatment of murine melanoma induced a rapid and complete regression in 9/11 animals, and offered long-term protection against a rechallenge in the majority of the cured mice. Palpable B16F1 tumors were injected with either a sterile 0.9% NaCl (vehicle controls) or 5 mg/ml LTX-401 once a day for three consecutive days. P<0.0001 (Mantel-Cox test); (B) Infiltrating CD3+ lymphocytes were detected in tumors following one single injection of LTX-401 (7 days post-injection) in a murine experimental animal model.</p>