10.1371/journal.pone.0148980.g007
Liv-Marie Eike
Liv-Marie
Eike
Brynjar Mauseth
Brynjar
Mauseth
Ketil André Camilio
Ketil
André Camilio
Øystein Rekdal
Øystein
Rekdal
Baldur Sveinbjørnsson
Baldur
Sveinbjørnsson
Intratumoral treatment induced complete regression in B16F1 melanomas.
Public Library of Science
2016
immunotherapeutic agent
cancer cell lines
pattern molecules
DAMP
Melanoma Cells
lytic cell death
cytoplasmic vacuolization
intratumoural injections
LTX
cell death
action studies
B 16 Melanoma
murine melanoma model
2016-02-16 07:56:29
Figure
https://plos.figshare.com/articles/figure/Intratumoral_treatment_induced_complete_regression_in_B16F1_melanomas_/2343448
<p>(A) The intratumoral treatment of murine melanoma induced a rapid and complete regression in 9/11 animals, and offered long-term protection against a rechallenge in the majority of the cured mice. Palpable B16F1 tumors were injected with either a sterile 0.9% NaCl (vehicle controls) or 5 mg/ml LTX-401 once a day for three consecutive days. P<0.0001 (Mantel-Cox test); (B) Infiltrating CD3+ lymphocytes were detected in tumors following one single injection of LTX-401 (7 days post-injection) in a murine experimental animal model.</p>