%0 Journal Article
%A Li, Yang
%A Xue, Dong
%A Lu, Wei
%A Wang, Chao
%A Liu, Zhao-Tie
%A Xiao, Jianliang
%D 2014
%T DMF as Carbon Source: Rh-Catalyzed α‑Methylation
of Ketones
%U https://acs.figshare.com/articles/journal_contribution/DMF_as_Carbon_Source_Rh_Catalyzed_Methylation_of_Ketones/2336410
%R 10.1021/ol403040g.s001
%2 https://ndownloader.figshare.com/files/3974020
%K DMF
%K Carbon Source
%K substrate scope
%K methylene fragment
%K Mechanistic studies
%K alkyl ketones
%K methylation process
%X An unprecedented Rh-catalyzed direct
methylation of ketones with N,N-dimethylformamide
(DMF) is disclosed.
The reaction shows a broad substrate scope, tolerating both aryl and
alkyl ketones with various substituents. Mechanistic studies suggest
that DMF delivers a methylene fragment followed by a hydride in the
methylation process.
%I ACS Publications