%0 Journal Article %A Li, Yang %A Xue, Dong %A Lu, Wei %A Wang, Chao %A Liu, Zhao-Tie %A Xiao, Jianliang %D 2014 %T DMF as Carbon Source: Rh-Catalyzed α‑Methylation of Ketones %U https://acs.figshare.com/articles/journal_contribution/DMF_as_Carbon_Source_Rh_Catalyzed_Methylation_of_Ketones/2336410 %R 10.1021/ol403040g.s001 %2 https://ndownloader.figshare.com/files/3974020 %K DMF %K Carbon Source %K substrate scope %K methylene fragment %K Mechanistic studies %K alkyl ketones %K methylation process %X An unprecedented Rh-catalyzed direct methylation of ketones with N,N-dimethyl­formamide (DMF) is disclosed. The reaction shows a broad substrate scope, tolerating both aryl and alkyl ketones with various substituents. Mechanistic studies suggest that DMF delivers a methylene fragment followed by a hydride in the methylation process. %I ACS Publications