Metallo-Folded Single-Chain Nanoparticles with Catalytic Selectivity Ana Sanchez-Sanchez Arantxa Arbe Juan Colmenero José A. Pomposo 10.1021/mz5001477.s001 https://acs.figshare.com/articles/journal_contribution/Metallo_Folded_Single_Chain_Nanoparticles_with_Catalytic_Selectivity/2290489 Mimicking the substrate specificity and catalytic activity of enzymes is of great interest for different fields (e.g., chemistry, biology, nanomedicine). Enhanced reaction rates using artificial, enzyme-mimic catalysts based on a variety of molecular structures and nanoentities (e.g., macrocyclic compounds, star and helical polymers, dendrimers) have been previously reported. However, examples of enzyme-sized soft entities displaying substrate specificity are certainly scarce. Herein, we report the synthesis and characterization of single-chain nanoparticles based on metallo-folded polymer chains containing complexed Cu­(II) ions showing catalytic specificity during the oxidative coupling of mixtures of chemically related terminal acetylene substrates. This work paves the way for the easy and efficient construction of other Pd-, Ni-, Co-, Fe-, Mn-, or Mo-containing soft nanoentities approaching the substrate specificity of natural enzymes for a variety of organic reactions. 2014-05-20 00:00:00 polymer nanoentitie variety Enhanced reaction rates substrate specificity enzyme e.g terminal acetylene substrates