TY - DATA T1 - Self-Immolative Polymersomes for High-Efficiency Triggered Release and Programmed Enzymatic Reactions PY - 2014/05/21 AU - Guhuan Liu AU - Xiaorui Wang AU - Jinming Hu AU - Guoying Zhang AU - Shiyong Liu UR - https://acs.figshare.com/articles/journal_contribution/Self_Immolative_Polymersomes_for_High_Efficiency_Triggered_Release_and_Programmed_Enzymatic_Reactions/2289835 DO - 10.1021/ja5030832.s001 L4 - https://ndownloader.figshare.com/files/3926344 KW - reductive milieu KW - SIPsomes disintegration KW - block copolymer vesicles KW - depolymerization KW - SIPsome encapsulation KW - UV light KW - cascade KW - Amphiphilic block copolymers KW - alternative approach KW - polymersome N2 - Stimuli-triggered disassembly of block copolymer vesicles or polymersomes has been conventionally achieved via solubility switching of the bilayer-forming block, requiring cooperative changes of most of the repeating units. Herein we report an alternative approach by incorporating hydrophobic blocks exhibiting stimuli-triggered head-to-tail cascade depolymerization features. Amphiphilic block copolymers bearing this motif self-assemble into self-immolative polymersomes (SIPsomes). By modular design of terminal capping moieties, visible light, UV light, and reductive milieu can be utilized to actuate SIPsomes disintegration into water-soluble small molecules and hydrophilic blocks. The design of SIPsomes allows for triggered drug co-release and controllable access toward protons, oxygen, and enzymatic substrates. We also demonstrate programmed (OR-, AND-, and XOR-type logic) enzymatic reactions by integrating SIPsome encapsulation and trigger/capping moiety-selective cascade depolymerization events. ER -