2281410
Matthew J. Blow
Matthew
J. Blow
Tyson A. Clark
Tyson
A. Clark
Chris G. Daum
Chris
G. Daum
Adam M. Deutschbauer
Adam M.
Deutschbauer
Alexey Fomenkov
Alexey
Fomenkov
Roxanne Fries
Roxanne
Fries
Jeff Froula
Jeff
Froula
Dongwan D. Kang
Dongwan
D. Kang
Rex R. Malmstrom
Rex
R. Malmstrom
Richard D. Morgan
Richard
D. Morgan
Janos Posfai
Janos
Posfai
Kanwar Singh
Kanwar
Singh
Axel Visel
Axel
Visel
Kelly Wetmore
Kelly
Wetmore
Zhiying Zhao
Zhiying
Zhao
Edward M. Rubin
Edward M.
Rubin
Jonas Korlach
Jonas
Korlach
Len A. Pennacchio
Len
A. Pennacchio
Richard J. Roberts
Richard J.
Roberts
Examples of candidate regulatory unmethylated sites.
Public Library of Science
2016
5C
DNA binding specificities
Prokaryotes DNA methylation acts
Type II MTases
DNA methylation
show motif specificities
620 DNA Methyltransferases
prokaryotic genome regulation
IIG
III
map DNA modifications
m 6A m 4C
organism
DNA methylation systems
2016-02-12 09:22:43
Figure
https://plos.figshare.com/articles/figure/Examples_of_candidate_regulatory_unmethylated_sites_/2281410
<p>In all panels bar charts show the extent of DNA methylation (inter-pulse duration ratio) at the candidate regulatory unmethylated site (blue) and, for comparison, at the ten immediately flanking upstream and downstream motif instances (red). The sequence interval covered in each chart varies due to the density of motifs across the respective genomes. <b>A)</b> Unmethylated sites are present upstream of the Hpa operon in four <i>Enterobacteria</i> species. In 3 cases, the unmethylated site is at the orthologous GATC, in <i>S</i>. <i>bongori</i>, the unmethylated site is located ~100bp upstream of the conserved sites. <b>B)</b> Conserved unmethylated site upstream of a PadR transcriptional regulator in <i>Arthrobacter</i> species. <b>C)</b> Cluster of unmethylated sites upstream of transcriptional regulator and sugar degradation operon in <i>Spirochaeta smaragdinae</i>. <b>D)</b> Cluster of non- or weakly-methylated sites throughout a non-ribosomal peptide synthase operon.</p>