10.1021/jo500771g.s002 Tapobrata Mitra Tapobrata Mitra Saibal Jana Saibal Jana Sharmila Pandey Sharmila Pandey Prabuddha Bhattacharya Prabuddha Bhattacharya Uttam K. Khamrai Uttam K. Khamrai Anakuthil Anoop Anakuthil Anoop Amit Basak Amit Basak Asymmetric Garratt–Braverman Cyclization: A Route to Axially Chiral Aryl Naphthalene–Amino Acid Hybrids American Chemical Society 2014 diastereoselective Axially hybrid Cyclization diastereoselectivity CD spectrum acid HybridsWe report density Asymmetric cyclization activation Naphthalene Garratt synthesis Chiral 3.48 formation Aryl naphthalene stereogenecity chiral energy barrier yield Computation kcal aryl M diastereomer M isomer 2014-06-20 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Asymmetric_Garratt_Braverman_Cyclization_A_Route_to_Axially_Chiral_Aryl_Naphthalene_Amino_Acid_Hybrids/2280937 We report the first example of a highly diastereoselective Garratt–Braverman cyclization leading to the synthesis of chiral aryl naphthalene–amino acid hybrids in excellent yields. The stereogenecity in the amino acid has induced high diastereoselectivity for the reaction. Computations based on density functional theory indicated a lower activation free energy barrier for the <b>M</b> isomer as compared to that for the <b>P</b> diastereomer (ΔΔ<i>G</i> = 3.48 kcal/mol). Comparison of the recorded CD spectrum of the product with the calculated one also supported the preferential formation of the <b>M</b> diastereomer.