%0 Journal Article
%A Modvig, Amalie
%A Andersen, Thomas
L.
%A Taaning, Rolf H.
%A Lindhardt, Anders T.
%A Skrydstrup, Troels
%D 2014
%T Two-Chamber Hydrogen Generation
and Application: Access
to Pressurized Deuterium Gas
%U https://acs.figshare.com/articles/journal_contribution/Two_Chamber_Hydrogen_Generation_and_Application_Access_to_Pressurized_Deuterium_Gas/2280934
%R 10.1021/jo500801t.s001
%2 https://ndownloader.figshare.com/files/3917344
%K DCl
%K deuterium gas
%K Olaparib
%K Access
%K Application
%K yield
%K Pressurized Deuterium GasHydrogen
%K derivative
%K method
%K synthesis
%K alkene
%K D 2.
%K isotope
%K reagent
%K CX
%K H 2
%K Generation
%K tetra
%K setup
%K alkyne
%K ketone
%K quinoline
%K HCl
%X Hydrogen
and deuterium gas were produced and directly applied in
a two-chamber system. These gaseous reagents were generated by the
simple reaction of metallic zinc with HCl in water for H2 and DCl in deuterated water for D2. The setup proved
efficient in classical Pd-catalyzed reductions of ketones, alkynes,
alkenes, etc. in near-quantitative yields. The method was extended
to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline
derivatives. Finally, CX-546 and Olaparib underwent efficient Ir-catalyzed
hydrogen isotope exchange reactions.
%I ACS Publications