Tambutet, Guillaume Becerril-Jiménez, Fabiola Dostie, Starr Simard, Ryan Prévost, Michel Mochirian, Philippe Guindon, Yvan Dual-Face Nucleoside Scaffold Featuring a Stereogenic All-Carbon Quaternary Center. Intramolecular Silicon Tethered Group-Transfer Reaction The design of a novel nucleoside scaffold that exhibits an all-carbon quaternary center is reported. This allows for both α- and β-anomers of a given 2′-deoxy-2′,2′-difluoro nucleoside analog (NA) to have potential biological activity. Using an intramolecular atom-transfer reaction, an all-carbon quaternary center was obtained without the use of heavy metals and/or harsh conditions. The chemistry developed is efficient, easily scalable and leads to novel libraries of molecules. exhibit;Scaffold;deoxy;Nucleoside;novel nucleoside scaffold;Featuring;analog;Tethered;NA;anomer;Center;molecule;center;scalable;Silicon;Quaternary;ReactionThe;Stereogenic;novel libraries;Intramolecular;quaternary;intramolecular 2014-11-07
    https://acs.figshare.com/articles/dataset/Dual_Face_Nucleoside_Scaffold_Featuring_a_Stereogenic_All_Carbon_Quaternary_Center_Intramolecular_Silicon_Tethered_Group_Transfer_Reaction/2238070
10.1021/ol502777r.s002