10.1021/ol502777r.s002
Guillaume Tambutet
Guillaume
Tambutet
Fabiola Becerril-Jiménez
Fabiola
Becerril-Jiménez
Starr Dostie
Starr
Dostie
Ryan Simard
Ryan
Simard
Michel Prévost
Michel
Prévost
Philippe Mochirian
Philippe
Mochirian
Yvan Guindon
Yvan
Guindon
Dual-Face Nucleoside Scaffold Featuring a Stereogenic
All-Carbon Quaternary Center. Intramolecular Silicon Tethered Group-Transfer
Reaction
American Chemical Society
2014
exhibit
Scaffold
deoxy
Nucleoside
novel nucleoside scaffold
Featuring
analog
Tethered
NA
anomer
Center
molecule
center
scalable
Silicon
Quaternary
ReactionThe
Stereogenic
novel libraries
Intramolecular
quaternary
intramolecular
2014-11-07 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Dual_Face_Nucleoside_Scaffold_Featuring_a_Stereogenic_All_Carbon_Quaternary_Center_Intramolecular_Silicon_Tethered_Group_Transfer_Reaction/2238070
The design of a novel
nucleoside scaffold that exhibits an all-carbon
quaternary center is reported. This allows for both α- and β-anomers
of a given 2′-deoxy-2′,2′-difluoro nucleoside
analog (NA) to have potential biological activity. Using an intramolecular
atom-transfer reaction, an all-carbon quaternary center was obtained
without the use of heavy metals and/or harsh conditions. The chemistry
developed is efficient, easily scalable and leads to novel libraries
of molecules.