10.1021/ol502777r.s002 Guillaume Tambutet Guillaume Tambutet Fabiola Becerril-Jiménez Fabiola Becerril-Jiménez Starr Dostie Starr Dostie Ryan Simard Ryan Simard Michel Prévost Michel Prévost Philippe Mochirian Philippe Mochirian Yvan Guindon Yvan Guindon Dual-Face Nucleoside Scaffold Featuring a Stereogenic All-Carbon Quaternary Center. Intramolecular Silicon Tethered Group-Transfer Reaction American Chemical Society 2014 exhibit Scaffold deoxy Nucleoside novel nucleoside scaffold Featuring analog Tethered NA anomer Center molecule center scalable Silicon Quaternary ReactionThe Stereogenic novel libraries Intramolecular quaternary intramolecular 2014-11-07 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Dual_Face_Nucleoside_Scaffold_Featuring_a_Stereogenic_All_Carbon_Quaternary_Center_Intramolecular_Silicon_Tethered_Group_Transfer_Reaction/2238070 The design of a novel nucleoside scaffold that exhibits an all-carbon quaternary center is reported. This allows for both α- and β-anomers of a given 2′-deoxy-2′,2′-difluoro nucleoside analog (NA) to have potential biological activity. Using an intramolecular atom-transfer reaction, an all-carbon quaternary center was obtained without the use of heavy metals and/or harsh conditions. The chemistry developed is efficient, easily scalable and leads to novel libraries of molecules.