Synthesis of Highly Substituted Imidazolidine-2,4-dione
(Hydantoin) through Tf<sub>2</sub>O‑Mediated Dual Activation
of Boc-Protected Dipeptidyl Compounds
Hui Liu
Zhimin Yang
Zhengying Pan
10.1021/ol502900j.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Highly_Substituted_Imidazolidine_2_4_dione_Hydantoin_through_Tf_sub_2_sub_O_Mediated_Dual_Activation_of_Boc_Protected_Dipeptidyl_Compounds/2233105
Highly substituted
chiral hydantoins were readily synthesized from
simple dipeptides in a single step under mild conditions. This reaction
proceeded through the dual activation of an amide and a <i>tert</i>-butyloxycarbonyl (Boc) protecting group by Tf<sub>2</sub>O-pyridine.
This method was successfully applied in the preparation of a variety
of biologically active compounds, including drug analogs and natural
products.
2014-11-21 00:00:00
dipeptide
CompoundsHighly
analog
Tf 2O
Boc
variety
Activation
Hydantoin
Substituted
method
Synthesi
Dipeptidyl
activation
hydantoin
compound
chiral
amide
Imidazolidine
preparation