Synthesis of Highly Substituted Imidazolidine-2,4-dione (Hydantoin) through Tf<sub>2</sub>O‑Mediated Dual Activation of Boc-Protected Dipeptidyl Compounds Hui Liu Zhimin Yang Zhengying Pan 10.1021/ol502900j.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Highly_Substituted_Imidazolidine_2_4_dione_Hydantoin_through_Tf_sub_2_sub_O_Mediated_Dual_Activation_of_Boc_Protected_Dipeptidyl_Compounds/2233105 Highly substituted chiral hydantoins were readily synthesized from simple dipeptides in a single step under mild conditions. This reaction proceeded through the dual activation of an amide and a <i>tert</i>-butyloxycarbonyl (Boc) protecting group by Tf<sub>2</sub>O-pyridine. This method was successfully applied in the preparation of a variety of biologically active compounds, including drug analogs and natural products. 2014-11-21 00:00:00 dipeptide CompoundsHighly analog Tf 2O Boc variety Activation Hydantoin Substituted method Synthesi Dipeptidyl activation hydantoin compound chiral amide Imidazolidine preparation