%0 Journal Article %A Cai, Yu %A Jalan, Ankur %A Kubosumi, Aaron R. %A Castle, Steven L. %D 2015 %T Microwave-Promoted Tin-Free Iminyl Radical Cyclization with TEMPO Trapping: A Practical Synthesis of 2‑Acylpyrroles %U https://acs.figshare.com/articles/journal_contribution/Microwave_Promoted_Tin_Free_Iminyl_Radical_Cyclization_with_TEMPO_Trapping_A_Practical_Synthesis_of_2_Acylpyrroles/2208733 %R 10.1021/ol5035047.s001 %2 https://ndownloader.figshare.com/files/3844264 %K Practical Synthesis %K Cyclization %K oxime %K Iminyl %K yield %K Toxic %K ether %K cyclization %K ketone %K acylpyrrole %K reagent %K TEMPO Trapping %K acceptor %K substrate %K Radical %K alkyne %K iminyl %K functionalized adducts %X Microwave-promoted iminyl radical cyclizations can be terminated by trapping with TEMPO, affording functionalized adducts. The use of alkynes as radical acceptors delivers a range of 2-acylpyrroles in good yields. Toxic and hazardous reagents, which are frequently employed in radical reactions, are not required. The O-phenyl oxime ether substrates are constructed in a single step from readily available ketones. %I ACS Publications