10.1021/jp510937r.s001
Eva Mazarío
Eva
Mazarío
Jorge Sánchez-Marcos
Jorge
Sánchez-Marcos
Nieves Menéndez
Nieves
Menéndez
Magdalena Cañete
Magdalena
Cañete
Alvaro Mayoral
Alvaro
Mayoral
Sara Rivera-Fernández
Sara
Rivera-Fernández
Jesús M. de la Fuente
Jesús
M. de la Fuente
Pilar Herrasti
Pilar
Herrasti
High Specific
Absorption Rate and Transverse Relaxivity
Effects in Manganese Ferrite Nanoparticles Obtained by an Electrochemical
Route
American Chemical Society
2015
High
nanoparticle
SAR
hyperthermia treatment
MRI
Manganese Ferrite Nanoparticles Obtained
toxicity
Transverse Relaxivity Effects
SPIONS
electrochemical synthesis method
ferrite
application
717 kHz frequency
r 2 value
2015-03-26 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/High_Specific_Absorption_Rate_and_Transverse_Relaxivity_Effects_in_Manganese_Ferrite_Nanoparticles_Obtained_by_an_Electrochemical_Route/2207977
Superparamagnetic
iron oxide-based nanoparticles (SPIONS) have
attracted an enormous amount of attention for their potential use
in biomedical applications, due to their good biocompatibility and
low toxicity. The current study considers citric acid-conjugated manganese
ferrite and its synergy to be used in MRI and in hyperthermia treatment,
thus showing theragnostic applications. High colloidal stability was
obtained with this functionalization. SPIONS with superparamagnetic
behavior of crystal sizes of approximately 20 nm were obtained via
an electrochemical synthesis method. One of the highest specific absorption
rate (SAR) values was achieved in this work (1661 W g<sup>–1</sup>), under a magnetic field of 30 mT at 717 kHz frequency, compared
with other magnetic ferrites in the literature. These nanoparticles
dissipate heat through Néel relaxation and, together with the
high SAR value obtained, indicate an excellent material for hyperthermia
treatment of cancer. In addition, these nanoparticles exhibit transverse
relaxivity behavior, with an <i>r</i><sub>2</sub> value
of 394 mM<sup>–1</sup> s<sup>–1</sup>, i.e., at least
two times higher than the value of a commercial magnetic contrast
agent based on iron oxides. Finally, no toxicity effects of these
nanoparticles are evidenced; as a result, these nanoparticles are
appropriate for in vivo application.