Reddy, Chada Raji Panda, Sujatarani A. Reddy, Motatipally Damoder Aza-Annulation of Enynyl Azides: A New Approach to Substituted Pyridines Synthesis of substituted pyridines through a novel aza-annulation of 2-en-4-ynyl azides, derived from MBH-acetates of acetylenic aldehydes, is described. A variety of enynyl azides having aryl, heteroaryl, and alkyl groups on the alkyne functionality successfully participated in the Ag-mediated annulation reaction to provide the corresponding 3,6-disubstituted pyridines. I<sub>2</sub>-Mediated cyclization was found to be controlled by the substituent on the alkyne functionality, which offered the 5-iodo-3,6-disubstituted pyridines from enynyl azides having an electron-rich substituent on the alkyne functionality. enynyl azides;alkyne functionality;pyridine;substituent 2015-02-20
    https://acs.figshare.com/articles/journal_contribution/Aza_Annulation_of_Enynyl_Azides_A_New_Approach_to_Substituted_Pyridines/2194213
10.1021/ol503752k.s001