Hajiali, Hadi Heredia-Guerrero, JoseĢ A. Liakos, Ioannis Athanassiou, Athanassia Mele, Elisa Alginate Nanofibrous Mats with Adjustable Degradation Rate for Regenerative Medicine The broad utilization of electrospun scaffolds of sodium alginate in tissue engineering is strongly limited by their high solubility in aqueous environments and by the difficulty to adjust their degradation dynamics. Here, an alternative strategy to enhance the stability and to control the degradability of alginate nanofibers is described by treating them with trifluoroacetic acid for specific time intervals. It is demonstrated that, by increasing the duration of the acid treatment procedure, a lower degradation rate of the resulting fibers in buffer solutions can be achieved. Furthermore, the produced mats are free from cytotoxic compounds and are highly biocompatible. The properties conferred to the alginate nanofibrous mats by the proposed method are extremely attractive in the production of innovative biomedical devices. Regenerative MedicineThe;tissue engineering;buffer solutions;acid treatment procedure;sodium alginate;trifluoroacetic acid;alginate nanofibers;Adjustable Degradation Rate;electrospun scaffolds;degradation rate;alginate nanofibrous mats;degradation dynamics;cytotoxic compounds;Alginate Nanofibrous Mats;time intervals;alternative strategy 2015-03-09
    https://acs.figshare.com/articles/journal_contribution/Alginate_Nanofibrous_Mats_with_Adjustable_Degradation_Rate_for_Regenerative_Medicine/2188681
10.1021/bm501834m.s001