%0 Journal Article %A Jang, Hongje %A Min, Dal-Hee %D 2015 %T Spherically-Clustered Porous Au–Ag Alloy Nanoparticle Prepared by Partial Inhibition of Galvanic Replacement and Its Application for Efficient Multimodal Therapy %U https://acs.figshare.com/articles/journal_contribution/Spherically_Clustered_Porous_Au_Ag_Alloy_Nanoparticle_Prepared_by_Partial_Inhibition_of_Galvanic_Replacement_and_Its_Application_for_Efficient_Multimodal_Therapy/2183554 %R 10.1021/nn506492s.s001 %2 https://ndownloader.figshare.com/files/3817720 %K nanoparticle %K spherically %K ratio %K hepatitis C virus NS 3 gene replicon %K DNAzyme %K multitherapy %K Porou %K photothermal conversion efficiency %K NIR %K irradiation %K Application %K thiolated %K doxorubicin %K liver cells %K FDz %K Galvanic Replacement %K oligonucleotide %K replacement reaction %K Efficient Multimodal TherapyThe polyvinylpyrrolidone %K pore diameter %K loading capacity %K payload %K PVP %K hepatitis C virus %K silver etching process %K hepatocarcinoma cell line %K 10 times %K Partial Inhibition %K Nanoparticle %K nanoshell %K codelivery %K Huh 7 %K Dox %K model system %K nanostructure %X The polyvinylpyrrolidone (PVP)-coated spherically clustered porous gold–silver alloy nanoparticle (PVP-SPAN) was prepared by low temperature mediated, partially inhibited galvanic replacement reaction followed by silver etching process. The prepared porous nanostructures exhibited excellent photothermal conversion efficiency under irradiation of near-infrared light (NIR) and allowed a high payload of both doxorubicin (Dox) and thiolated dye-labeled oligonucleotide, DNAzyme (FDz). Especially, PVP-SPAN provided 10 times higher loading capacity for oligonucleotide than conventional hollow nanoshells due to increased pore diameter and surface-to-volume ratio. We demonstrated highly efficient chemo-thermo-gene multitherapy based on codelivery of Dox and FDz with NIR-mediated photothermal therapeutic effect using a model system of hepatitis C virus infected human liver cells (Huh7 human hepatocarcinoma cell line containing hepatitis C virus NS3 gene replicon) compared to conventional hollow nanoshells. %I ACS Publications