Meng, Jingjing Gao, Min Lv, Hui Zhang, Xumu Highly Enantioselective Hydrogenation of <i>ο</i>‑Alkoxy Tetrasubstituted Enamides Catalyzed by a Rh/(<i>R</i>,<i>S</i>)‑JosiPhos Catalyst Rh/(<i>R,S</i>)-JosiPhos complex-catalyzed asymmetric hydrogenation of <i>o</i>-alkoxy tetrasubstituted enamides has been achieved, and it furnished a set of β-amino alcohol analogues in high yields and excellent enantiomeric excesses (>99% conversion, up to 99% ee).This method provides valuable chiral building blocks in chiral pharmaceuticals and useful motifs for catalysts. motif;chiral building blocks;Tetrasubstituted;yield;enamide;Rh;hydrogenation;ee;Alkoxy;tetrasubstituted;enantiomeric;method;CatalystRh;chiral pharmaceuticals;alcohol analogues;excess;Enantioselective Hydrogenation;Catalyzed;conversion;Enamide;catalyst 2015-04-17
    https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Hydrogenation_of_i_i_Alkoxy_Tetrasubstituted_Enamides_Catalyzed_by_a_Rh_i_R_i_i_S_i_JosiPhos_Catalyst/2175742
10.1021/acs.orglett.5b00401.s001