Tan, Xuyu Li, Ben B. Lu, Xueguang Jia, Fei Santori, Clarissa Menon, Priyanka Li, Hui Zhang, Bohan Zhao, Jean J. Zhang, Ke Light-Triggered, Self-Immolative Nucleic Acid-Drug Nanostructures The simultaneous intracellular delivery of multiple types of payloads, such as hydrophobic drugs and nucleic acids, typically requires complex carrier systems. Herein, we demonstrate a self-deliverable form of nucleic acid–drug nanostructure that is composed almost entirely of payload molecules. Upon light activation, the nanostructure sheds the nucleic acid shell, while the core, which consists of prodrug molecules, disintegrates via an irreversible self-immolative process, releasing free drug molecules and small molecule fragments. We demonstrate that the nanostructures exhibit enhanced stability against DNase I compared with free DNA, and that the model drug (camptothecin) released exhibits similar efficacy as free, unmodified drugs toward cancer cells. cancer cells;acid shell;payload molecules;model drug;DNA;light activation;drug molecules;molecule fragments;prodrug molecules;intracellular delivery;carrier systems;nanostructures exhibit 2015-05-20
    https://acs.figshare.com/articles/journal_contribution/Light_Triggered_Self_Immolative_Nucleic_Acid_Drug_Nanostructures/2165230
10.1021/jacs.5b00795.s001