Jindal, Garima Sunoj, Raghavan B. Deciphering the Origin of Stereoinduction in Cooperative Asymmetric Catalysis Involving Pd(II) and a Chiral Brønsted Acid The density functional (M06) computations on a cooperative multicatalytic reaction involving palladium acetate and a chiral Brønsted acid in the conversion of an indenyl cyclobutanol to spirocyclic indene bearing a quaternary carbon ring junction are reported. A chiral Pd-<i>bis</i>-phosphate is identified as the active catalyst in the enantioselective ring expansion as compared to alternative possibilities wherein the chiral phosphate/phosphoric acid is in the outer sphere of palladium. The enantiocontrolling transition state exhibited more effective C–H···π interactions, lower distortion of the catalyst, and an orthogonal orientation of the bulky phosphate ligands. spirocyclic indene;orthogonal orientation;palladium acetate;Cooperative Asymmetric Catalysis;quaternary carbon ring junction;enantiocontrolling transition state;Chiral Br ønsted AcidThe density;phosphate ligands;enantioselective ring expansion;indenyl cyclobutanol;alternative possibilities;chiral Br ønsted acid;multicatalytic reaction;catalyst 2015-06-19
    https://acs.figshare.com/articles/journal_contribution/Deciphering_the_Origin_of_Stereoinduction_in_Cooperative_Asymmetric_Catalysis_Involving_Pd_II_and_a_Chiral_Br_nsted_Acid/2156779
10.1021/acs.orglett.5b00860.s001