%0 Figure %A Zhou, Jiping %A G. Joplin, Denise %A Cross, Janet V. %A Templeton, Dennis J. %D 2013 %T SFN inhibits mPGES-1 expression and PGE2 production in tumors in vivo. %U https://plos.figshare.com/articles/figure/_SFN_inhibits_mPGES_1_expression_and_PGE2_production_in_tumors_in_vivo_/211752 %R 10.1371/journal.pone.0049744.g009 %2 https://ndownloader.figshare.com/files/541263 %K inhibits %K mpges-1 %K pge2 %K tumors %X

2.5 × 106 A549 cells were injected subcutaneously on the flank of athymic nude mice. After 6 weeks, animals were treated with PBS vehicle (control) or 0.5 mg SFN by intraperitoneal injection and sacrificed 24 hours later. Tumor tissue samples were weighed and frozen for subsequent RT-PCR assay (A), immunoblot analysis (B) and PGE2 measurement (C). The results in A and B are expressed as fold changes relative to PBS treated mice (mean ± SEM; n = 4). *, P<0.05, **, P<0.01, (Student's t test). Four mice in each group (PBS vehicle or SFN treated) were used in this experiment.

%I PLOS ONE